The Hulda Clark ParaZapper
The position of CD47 in cell migration was first demonstrated for neutrophils, the place CD47 blocking antibodies inhibited transmigration of neutrophils and monocytes through the endothelium. These results had been shown to be dependent on avb3 integrins, which work together with and are activated by CD47 on the plasma membrane. Originally discovered by Irving Weissman’s […]